Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation.

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成果类型：

期刊论文

作者：

He, Ming-chao;Shi, Zhe;Sha, Nan-nan;Chen, Nan;Peng, Shi-yu;...

通讯作者：

Wang, Yong-jun;Yuan, Ti-fei;Zhang, Yan

作者机构：

[Chen, Nan; Wang, Yong-jun; Sha, Nan-nan; Zhang, Yan; He, Ming-chao] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Spine Dis Res Inst, Shanghai 200032, Peoples R China.

[Peng, Shi-yu; Yuan, Ti-fei; Shi, Zhe] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai 201108, Peoples R China.

[Liao, Duan-fang; Shi, Zhe] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

[Dong, Xiao-li; Wong, Man-sau] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China.

[Wang, Yong-jun] Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 200032, Peoples R China.

通讯机构：

[Wang, Yong-jun; Yuan, Ti-fei; Zhang, Yan] S

Shanghai Univ Tradit Chinese Med, Longhua Hosp, Spine Dis Res Inst, Shanghai 200032, Peoples R China.

Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 201108, Peoples R China.

Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China.

语种：

英文

关键词：

Depression-like behavior;LPS;Microgliosis;Neuroinflammation;Paricalcitol

期刊：

Biochemical Pharmacology

ISSN：

0006-2952

年：

2019

卷：

163

页码：

1-8

DOI：

10.1016/j.bcp.2019.01.021

基金类别：

Paricalcitol was kindly provided by Prof. Yan-Chun Li, Department of Medicine, University of Chicago. This work was supported by the National Natural Science Foundation of China ( 81730107 , 81774329 ), Hundred Talents Program from Shanghai Municipal Commission of Health and Family Planning ( 2018BR03 ), Natural Science Foundation of Shanghai ( 17ZR1430800 ), Program for Innovative Research Team ( 2015RA4002 ) and National Key R & D Program ( 2018YFC1704302 ) from Ministry of Science and Technology of China , China Postdoctoral Science Foundation ( 2018T110405 ), and Longhua Medical Innovation Team Program ( LYCX-01 ). T. Yuan is also sponsored by the Science and Technology Commission of Shanghai Municipality ( 18QA1403700 / Shanghai Rising Star Program , 18JC1420304 , 18140901700 ).

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院系归属：

药学院

摘要：

Depression is highly prevalent in patients suffering from chronic inflammatory diseases. Dysregulated neuroinflammation and concomitant activated microglia play a pivotal role in the pathogenesis of depression. Paricalcitol (Pari), a vitamin D2 analogue, has been demonstrated to exert anti-inflammative effects on renal and cardiovascular diseases. In this study, mice were pretreated with Pari before being induced to acute depression-like behaviors by systemic lipopolysaccharide (LPS) injection. To determine the therapeutic effects of Pari, alte...

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Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation.

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