Therapeutic potency and possible mechanism of Wuhu decoction underlying asthmatic progression via Th1/Th2 imbalance

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成果类型：

期刊论文

作者：

Hu, Yan;Wang, Mengqing;Luo, Yinhe;Xie, Jing;Jiao, Luojia;...

通讯作者：

Hu, Y;Jiao, LJ

作者机构：

[Xie, Jing; Deng, Yijue; Yao, Bing; Hu, Yan; Wang, Mengqing; Luo, Yinhe] Hunan Univ Chinese Med, Dept Pediat, Affiliated Hosp 1, 95,Shaoshan Middle Rd, Changsha 410007, Peoples R China.

[Luo, Yinhe] Hunan Univ Chinese Med, Teaching & Res Off Chinese & Western Combinat, Changsha, Peoples R China.

[Jiao, Luojia] Hunan Univ Chinese Med, Dept Org Personnel Dept, 300,Bachelor Rd, Changsha 410208, Peoples R China.

[Tang, Wei] Hunan Univ Chinese Med, Dept Acupuncture & Massage, Affiliated Hosp 1, Changsha, Peoples R China.

通讯机构：

[Jiao, LJ ; Hu, Y ] H

Hunan Univ Chinese Med, Dept Pediat, Affiliated Hosp 1, 95,Shaoshan Middle Rd, Changsha 410007, Peoples R China.

Hunan Univ Chinese Med, Dept Org Personnel Dept, 300,Bachelor Rd, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Th1/Th2 balance;Wuhu decoction;antisense long non-coding RNA TRPM2 (lncTRPM2-AS);cough variant asthma (CVA)

期刊：

JOURNAL OF THORACIC DISEASE

ISSN：

2072-1439

年：

2025

卷：

期：

页码：

265-277

DOI：

10.21037/jtd-24-804

基金类别：

Research Project of Education Department of Hunan Province [20B440]; Natural Science Foundation of Hunan Province [2021JJ40422]; Scientific Research Project of Traditional Chinese Medicine in Hunan Province [A2024027]; Mengqing Wang National Prestigious Chinese Medicine Expert Inheritance Studio

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

针灸推拿与康复学院

摘要：

BACKGROUND: Cough variant asthma (CVA) is a disease with no definitive diagnosis or pathogenic causes, and still lacks effective and safe treatment. Wuhu decoction is a traditional Chinese medicine with potential effects against CVA, of which underlying mechanism remains elusive. The aim of this study is to explore the therapeutic potential of Wuhu decoction against CVA. METHODS: The CVA mice model was established by ovalbumin (OVA) treatment. The airway hyperresponsiveness and remodeling were assessed. The pulmonary inflammatory injury was determined by counting of inflammatory cells and seru...

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Therapeutic potency and possible mechanism of Wuhu decoction underlying asthmatic progression via Th1/Th2 imbalance

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