Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Xin;Xu, Xiaosa;Li, Jinping;Shi, Liying;Zeng, Ying;...

通讯作者：

Li, JP

作者机构：

[Jia, Lujuan; Li, Yuhong; Shi, Liying; Li, Jinping; Liu, Xin; Li, JP; Xu, Xiaosa] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmachem, Chang Sha, Hunan, Peoples R China.

[Li, Jinping; Li, JP] Cent South Univ, Hunan Key Lab Diagnost & Therapeut Drug Res Chron, Chang Sha, Hunan, Peoples R China.

[Zeng, Ying] Hunan Univ Tradit Chinese Med, Hosp 1, Dept Cardiovasc Med, Chang Sha, Hunan, Peoples R China.

[Liu, Wei; Tang, Siyuan] Cent South Univ, Dept Community Nursing, Changsha, Hunan, Peoples R China.

[Zhang, Jie] Cent South Univ, Xiangya Hosp 3, Pharm Dept, Changsha, Hunan, Peoples R China.

通讯机构：

[Li, JP ] C

Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmachem, Chang Sha, Hunan, Peoples R China.

Cent South Univ, Hunan Key Lab Diagnost & Therapeut Drug Res Chron, Chang Sha, Hunan, Peoples R China.

语种：

英文

关键词：

NF-κB;RANKL;isobavachalcone;miR-193-3p;osteoclast

期刊：

Bioscience, Biotechnology, and Biochemistry

ISSN：

0916-8451

年：

2023

卷：

期：

页码：

960-971

DOI：

10.1093/bbb/zbad075

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Inhibition of extensive osteoclastogenesis and bone resorption is considered a potential therapeutic target for the treatment of osteoporosis. Isobavachalcone (IBC) is derived from the traditional Chinese herb Psoralea corylifolia Linn. We showed that IBC dose-dependently suppressed receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis in bone marrow monocyte/macrophage (BMMs) and osteoclastic bone-resorption function without cytotoxicity at a dose of no more than 8 µmin vitro. Mechanistically, the results of w...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问