Total flavonoids from celery suppresses RANKL-induced osteoclast differentiation and bone resorption function via attenuating NF-κB and p38 pathways in RAW264.7 cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jia, Lujuan;Shi, Liying;Li, Jinping;Zeng, Ying;Tang, Siyuan;...

通讯作者：

Li, JP

作者机构：

[Jia, Lujuan; Shi, Liying; Li, Jinping; Liu, Xin; Li, JP] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmachem, 172 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

[Zeng, Ying; Mo, Xinmin] Hunan Univ Tradit Chinese Med, Hosp 1, 105 Shao Shan Rd, Changsha, Hunan, Peoples R China.

[Liu, Wei; Tang, Siyuan] Cent South Univ, Sch Nursing, 172 Tong Zi Po Rd, Changsha, Hunan, Peoples R China.

通讯机构：

[Li, JP ] C

Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmachem, 172 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Osteoclast;Total flavonoids;MAPKs;NF-kappa B;Osteoporosis

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2020

卷：

页码：

103949

DOI：

10.1016/j.jff.2020.103949

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 81273816 , 81774379 , 81370974 ); the Fundamental Research Funds for the Central Universities of Central South University ( 1053320183583 ); and the Fund for the Key Laboratory of Hunan Province, China ( 2017TP1004 ).

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Skeletal diseases caused by excessive activation of osteoclasts seriously affect elderly's health. Therefore, inhibiting excessive activation of osteoclasts become effective therapeutic strategy for osteoporosis. Celery, a traditional and popular Chinese vegetable with high nutritional value, is rich in flavonoids which have a variety of pharmacological activities. The present study aimed to determine the pharmacological effect of total flavonoids of celery (TFC) on osteoclastogenesis, and to explore the molecular mechanisms. Results showed tha...

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Total flavonoids from celery suppresses RANKL-induced osteoclast differentiation and bone resorption function via attenuating NF-κB and p38 pathways in RAW264.7 cells

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