Inhibition of macrophage-derived foam cell formation by ezetimibe via the caveolin-1/MAPK pathway

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成果类型：

期刊论文

作者：

Qin, Li;Yang, Yun-Bo;Yang, Yi-Xin;Zhu, Neng;Liu, Zheng;...

通讯作者：

Liao, Duan- Fang

作者机构：

[Li, Shun-Xiang; Yang, Yun-Bo; Zheng, Xi-Long; Liu, Zheng; Liao, Duan- Fang; Qin, Li; Ni, Ya-Guang] Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Yang, Yun-Bo; Yang, Yi-Xin] Univ Western Ontario, London Hlth Sci Ctr, Matthew Mailing Ctr Translat Transplantat Studies, London, ON, Canada.

[Zhu, Neng] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Calgary, AB, Canada.

[Liao, Duan- Fang] Hunan Univ Chinese Med, Hanpu Sci & Educ Dist, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Liao, Duan- Fang] H

Hunan Univ Chinese Med, Hanpu Sci & Educ Dist, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

MAPK;atherosclerosis;caveolin-1;ezetimibe;foam cell

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2016

卷：

期：

页码：

182-192

DOI：

10.1111/1440-1681.12524

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000946, 81270359, 81173047, 31371161]; Key project of Hunan Provincial Education DepartmentHunan Provincial Education Department [15A138, 12A107]; construct program of Pharmaceutical Science key discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Ezetimibe, a selective inhibitor of intestinal cholesterol absorption, effectively reduces plasma cholesterol, but its effect on atherosclerosis is unclear. Foam cell formation has been implicated as a key mediator during the development of atherosclerosis. The purpose of this study was to investigate the effects of ezetimibe on foam cell formation and explore the underlying mechanism. Our results showed that ezetimibe reduced atherosclerotic lesions in apolipoprotein E deficient (apoE-/-) mice by lowering cholesterol levels. Treatment of macro...

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Inhibition of macrophage-derived foam cell formation by ezetimibe via the caveolin-1/MAPK pathway

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