Multiomics analysis demonstrated a strong correlation between lipid-mediated chronic kidney disease and stroke: Potential benefits of affected patient cohorts

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成果类型：

期刊论文

作者：

Liu, Yan-song;Zhang, Jian-hang;Han, Jia-yue;Long, Yu-yan;Liu, Yu-chen;...

通讯作者：

Liu, WH

作者机构：

[Tan, Shi-min; Cai, Si-le; Li, Hua; Mao, Kai-ni; Zhang, Jian-hang; Song, Zhi-guang; Han, Jia-yue; Liu, Wang-hua; Liu, Yu-chen; Peng, Si-min; Song, Wan-ying; Liu, Yan-song; Long, Yu-yan; Feng, Yu-jing; Lin, Li-hua; Yang, Jing-yi] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

[Tan, Shi-min; Cai, Si-le; Li, Hua; Mao, Kai-ni; Zhang, Jian-hang; Song, Zhi-guang; Han, Jia-yue; Liu, Yu-chen; Peng, Si-min; Song, Wan-ying; Liu, Yan-song; Liu, Wang-hua; Long, Yu-yan; Feng, Yu-jing; Lin, Li-hua; Yang, Jing-yi] Hunan Univ Chinese Med, Key Lab TCM Heart & Lung Syndrome Differentiat & M, Changsha 410208, Hunan, Peoples R China.

[Tan, Shi-min; Cai, Si-le; Mao, Kai-ni; Zhang, Jian-hang; Song, Zhi-guang; Han, Jia-yue; Peng, Si-min; Song, Wan-ying; Liu, Yan-song; Liu, Wang-hua; Long, Yu-yan; Feng, Yu-jing; Lin, Li-hua; Yang, Jing-yi] Hunan Univ Chinese Med, Hunan Engn Technol Res Ctr Med & Funct Food, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Liu, WH ] H

Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Chronic kidney disease;Stroke;Lipids;Multiomics;Kidney-brain correlation;Targeted prevention;Machine learning;AI;Predictive modeling;Patient stratification

期刊：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES

ISSN：

1052-3057

年：

2025

卷：

期：

页码：

108285

DOI：

10.1016/j.jstrokecerebrovasdis.2025.108285

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

中医诊断研究所

摘要：

Objective Patients with chronic kidney disease (CKD) exhibit a disproportionately elevated risk of stroke, frequently compounded by renal impairment. Therapeutic strategies for stroke based on Traditional Chinese Medicine's 'kidney–brain axis' theory demonstrate clinical efficacy, indicating that there may be a potential association between chronic kidney disease and stroke, which needs further exploration and verification. Patients with chronic kidney disease (CKD) exhibit a disproportionately elevated risk of stroke, frequently compounded by...

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Multiomics analysis demonstrated a strong correlation between lipid-mediated chronic kidney disease and stroke: Potential benefits of affected patient cohorts

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