期刊论文

中文

辽宁中医药大学学报

1673-842X

2019

21

6

32-35

10.13194/j.issn.1673-842x.2019.06.008

国家自然科学基金项目(81473616) 湖南省科技厅重点研发计划资助项目(2016DK2002) 湖南省教育厅重点资助项目(15A142) 湖南省中药粉体与创新药物省部共建国家重点实验室开放基金资助项目(ZYFT201503).

本校为第一机构

目的 :观察七芍方对自发性高血压大鼠心室重构的保护效应,进一步探讨其具体机制。方法 :将40只13周龄雄性自发性高血压大鼠按照完全随机原则分为模型组、中药干预组、缬沙坦组,同时选取10只13周龄的Wistar大鼠设置空白对照组,其中中药干预组予七芍方灌胃,缬沙坦组予缬沙坦灌胃,模型组及空白对照组予相同体积的无菌用水灌胃,连续干预12周;予各组大鼠监测血压;采取免疫分析法对各组大鼠IL-1β、IL-10数值进行测定;采取Masson染色对心脏的形态学进行观察;采取Westernblot法测定心脏组织IL-1β、IL-10表达水平。结果 :与模型组大鼠对比,中药组大鼠血压下降显著（P

Objective:To observe the protective effect of Qishao Decoction on ventricular remodeling in spontaneously hypertensive rats and further to explore its specific mechanism.Methods:Forty-five15-week-old male spontaneously hypertensive rats were divided into model group,Chinese medicine group(Qishao Decoction group),and valsartan group according to the principle of randomization.Twelve Wistar rats aged 15 weeks were selected to set up health.The rats in the traditional Chinese medicine group were given Qishao Decoction by gavage,the valsartan group...