期刊论文

Experimental study on the inhibition of huangbaiye on HSV-2 in vitro

中文

中国临床药理学与治疗学

1009-2501

2003

8

3

308-310

10.3969/j.issn.1009-2501.2003.03.019

湖南省教育厅科研项目

本校为第一机构

目的:探讨黄白液治疗预防复发性生殖器疱疹的作用.方法:采用体外细胞培养技术观察黄白液对Ⅱ型单纯疱疹病毒(HSV-2)复制的抑制作用,并与环胞苷、阿昔洛韦作比较.结果:黄白液对HSV-2的复制有明显抑制作用,其最小有效浓度为 2.5 g*L-1,治疗指数为3,黄白液 2.5 g*L-1对HSV-2的抑制作用不亚于环胞苷,两者抑毒指数为 2.83,阿昔洛韦抗HSV-2作用较强,抑制指数为 5.31.结论:黄白液可治疗复发性生殖器疱疹,与其抑制HSV-2的复制有关.

AIM: To study the effects of the huangbaiye in the treatment o f recurrent genital herpes. METHODS: The inhibitory activity of huangbaiye on HSV-2 was observed from the cells cultured in vitro in compariso n with cyclo-C and acyclovir. RESULTS: The huangbaiye showed no table direct inhibitory effects on HSV-2 in vitro. The minimal effective concentration was 2.5 g·L -1 , the therapeutic index was 3, the inhibitory activity of huangbaiye ( 2.5 g·L -1 ) was not less than t hat of cyclo-C, and the inhibition virus index was 2.83 in both huangbai...