期刊论文

Compound Qishao Jiangya tablet reduces blood pressure in mesenteric artery of SHR rats by decreasing the deposition of type Ⅰ and type III collagen

中文

中国临床药理学与治疗学

1009-2501

2019

24

12

1364-1370

10.12092/j.issn.1009-2501.2019.12.008

湖南省中医药管理局重点项目(201910) 湖南省科技厅项目(2018SK51203) 中医内科重大疾病防治及转化教育部重点实验室开放基金(ZYNK201703) 研究生校级创新课题(2018CX37) 国家自然科学基金(81473616)。

本校为第一机构

目的:探究复方七芍降压片对自发性高血压大鼠( SHR)血压及血管重塑的作用机制。方法: SHR大鼠随机分为模型组、厄贝沙坦片组、复方七芍降压片组,每组10只,另设10只WKY大鼠为正常对照组,给药6周,无创血压仪测量各周大鼠血压变化; HE染色观察大鼠肠系膜动脉病理变化并测量管壁厚度、血管中膜厚度及相同位置的管腔直径,比值记为WT;免疫组化法检测肠系膜动脉中基质金属蛋白酶-2( MMP-2)及Ⅰ、Ⅲ型胶原蛋白( COⅠ、COⅢ)表达情况。结果:给药6周后,与正常对照组比较,模型组大鼠各周血压均明显升高( P < 0.01), 管壁厚度及WT值增高( P < 0.01或P < 0.05), 肠系膜动脉中MMP-2及 Ⅰ、Ⅲ型胶原蛋白表达均明...

AIM: To explore the mechanism of compound Qishao Jiangya tablet on blood pressure and vascular remodeling in spontaneously hypertensive rats ( SHR). METHODS: SHR rats were randomly divided into model group,irbesartan tablet group and compound Qishao Jiangya tablet group,10 rats in each group; Another 10 WKY rats were used as normal control group; All received administration for 6 weeks; noninvasive sphygmomanometer was used to measure the changes of blood pressure in rats; HE staining was used to observe the pathological changes of mesenteric a...