期刊论文

Study on the Forming Technology of Fufang Shenyan Tablets

中文

临床医学工程

1674-4659

2012

19

6

968-970

10.3969/j.issn.1674-4659.2012.06.0968

本校为其他机构

目的 确定复方肾炎片成型工艺.方法 采用颗粒合格率、休止角、吸湿率及可压性为考查指标,考查了复方肾炎片制粒的配方;对颗粒临界相对湿度、颗粒流动性、堆密度进行了测定;对片型片重进行了选择.结果 复方肾炎片制粒的配方以药粉∶可溶性淀粉∶3-CD为80∶15∶5为佳；颗粒临界相对湿度为65％,颗粒休止角为33.1°,颗粒堆密度为0.49 g/cm3;选择了0.6 g/片的异型片；确定了薄膜包衣工艺和整个成型工艺流程.结论 本试验为复方肾炎片成型工艺提供了试验依据.

Objective To determine the forming technology of Fufang Shenyan tablets. Methods With granules qualified rate, zero angle, moisture absorption rate, compressibility as the reviewing index, the compounding of Fufang Shenyan tablets were reviewed; CMC, flowability, bulk density of granules; elected tablet form, tablet weight were determined. Results The best compounding of Fufang Shenyan tablets was medicine powder, starch and β-CD control about 80 ： 15 ： 5; CMC of granules was 65%, zero angle of granules was 33.1°, bulk density of granules w...