Pokemon inhibits transforming growth factor β-smad4-related cell proliferation arrest in breast cancer through specificity protein 1

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成果类型：

期刊论文

作者：

Chen, Ling;Zhong, Jing;Liu, Jiang-Hua;Liao, Duan-Fang;Shen, Ying-Ying;...

通讯作者：

Zu, XY

作者机构：

[Shen, Ying-Ying; Peng, Xiu-Da; Zhong, Jing; Zhong, Xiao-Lin; Zu, Xu-Yu; Xiao, Xiao; Ding, Wen-Jun; Chen, Ling; Liu, Jiang-Hua] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Xiong, Wei] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis, Minist Hlth, Changsha, Hunan, Peoples R China.

[Xiong, Wei] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Changsha, Hunan, Peoples R China.

通讯机构：

[Zu, XY ] U

Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

kruppel like factor;pokemon;Smad4 protein;small interfering RNA;transcription factor Sp1;transforming growth factor beta;unclassified drug;Article;breast cancer;cancer cell line;cell cycle arrest;cell proliferation;cell viability;cloning;colony formation;down regulation;fluorescence microscopy;gel mobility shift assay;gene deletion;gene expression regulation;gene overexpression;human;human cell;immunoprecipitation;luciferase assay;microarray analysis;MTS assay;polyacrylamide gel electrophoresis;promoter region;protein expression;real time polymerase chain reaction;signal transduction;Western blotting

期刊：

JOURNAL OF BREAST CANCER

ISSN：

1738-6756

年：

2019

卷：

期：

页码：

15-28

DOI：

10.4048/jbc.2019.22.e11

基金类别：

This study is supported by the Major Program of National Health and Family Planning Commission of Hunan (A2017013), Scientific Research Fund of Education Department of Hunan Province (16B230), National Natural Science Foundation of China (81272355, 81773294), Guangxi Provincial Natural Science Foundation (2015GXNSFEA139003), and Hunan Provincial Natural Science Foundation of China (2018JJ3464).

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Purpose: Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor β (TGFβ)-Smad4 pathway-dependent proliferation arrest of breast cancer cells via specificity protein 1 (SP1). Methods: Over-expressing plasmid or small interfering RNA (siRNA) transfection was used to regulate Pokemon levels. The EdU incorporation assay, MTS assay...

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Pokemon inhibits transforming growth factor β-smad4-related cell proliferation arrest in breast cancer through specificity protein 1

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