MicroRNA-376c Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting to Transforming Growth Factor-Alpha

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成果类型：

期刊论文

作者：

Jin, Yi;Peng, Dan*;Shen, Yi;Xu, Min;Liang, Ying;...

通讯作者：

Peng, Dan

作者机构：

[Xu, Min; Shen, Yi; Peng, Dan; Jin, Yi] Cent S Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410000, Hunan, Peoples R China.

[Liang, Ying] Cent South Univ Forestry & Technol, Natl Engn Lab Rice & Byprod Deep Proc, Changsha, Hunan, Peoples R China.

[Xiao, Bowen] Cent Hosp Changsha, Thorac & Cardiovasc Surg Ward, Changsha, Hunan, Peoples R China.

[Lu, Jing] Hunan Univ Chinese Med, Sch Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Peng, Dan] C

Cent S Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410000, Hunan, Peoples R China.

语种：

英文

期刊：

DNA and Cell Biology

ISSN：

1044-5498

年：

2013

卷：

期：

页码：

302-309

DOI：

10.1089/dna.2013.1977

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-376c expression level was decreased while transforming growth factor-alpha (TGFA) mRNA expression levels were increased in osteosarcoma tissues and cell lines, and we identified TGFA as a novel direct target of miR-376c. Overexpression of miR-376c suppressed TGFA expression and the expression of its downstream signaling molecule such as epidermal growth factor receptor, and attenuated cell proliferation an...

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MicroRNA-376c Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting to Transforming Growth Factor-Alpha

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