Inhibitory effects of lupane-type triterpenoid saponins from the leaves of Acanthopanax gracilistylus on lipopolysaccharide-induced TNF-alpha, IL-1 beta and high-mobility group box 1 release in macrophages

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成果类型：

期刊论文

作者：

Zou, Qin-Peng;Liu, Xiang-Qian*;Huang, Jian-Jun;Yook, Chang-Soo;Whang, Wan-Kyunn;...

通讯作者：

Liu, Xiang-Qian

作者机构：

[Zou, Qin-Peng] Changsha Broad Ocean Biosci & Tech Co Ltd, Changsha 410205, Hunan, Peoples R China.

[Liu, Xiang-Qian] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

[Huang, Jian-Jun] Cent S Univ, Dept Clin Biochem, Xiangya Med Coll, Changsha 410013, Hunan, Peoples R China.

[Yook, Chang-Soo] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea.

[Whang, Wan-Kyunn] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea.

通讯机构：

[Liu, Xiang-Qian] H

Hunan Univ Chinese Med, Sch Pharm, Hanpu Sci & Educ, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

high-mobility group box 1;lupane-type triterpenoid saponins;Acanthopanax gracilistylus;tumor necrosis factor-alpha;interleukin-1 beta;nuclear factor-kappa B

期刊：

Molecular Medicine Reports

ISSN：

1791-2997

年：

2017

卷：

期：

页码：

9149-9156

DOI：

10.3892/mmr.2017.7767

基金类别：

Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [11JJ2042]; Key Projects of Changsha City Science and Technology Bureau [k1403122-31]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Acanthopanax gracilistylus (AGS) has long been used in traditional Chinese medicine for the treatment of various inflammatory diseases. 3-O-beta-D-glucopyranosyl 3 alpha, 11 alpha-dihydroxylup-20(29)-en-28-oic acid, acantrifoside A, acankoreoside D, acankoreoside B and acankoreoside A are major lupane-type triterpenoid saponins derived from AGS. In the present study, these five saponins were isolated from AGS by chromatography and their anti-inflammatory activities were investigated in lipopolysaccharide (LPS)-treated RAW264.7 macrophages. Cell viability was evaluated by MTT assay. Tumor necro...

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Inhibitory effects of lupane-type triterpenoid saponins from the leaves of Acanthopanax gracilistylus on lipopolysaccharide-induced TNF-alpha, IL-1 beta and high-mobility group box 1 release in macrophages

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