期刊论文

Experimental Study of Kang＇ai Fangyi Tablet＇s Curative Effect Against 4T1 Mice Breast Cancer

中文

湖南中医药大学学报

1674-070X

2014

34

4

6-9

10.3969/j.issn.1674-070X.2014.04.003.006.04

国家自然科学基金资助项目（81373550）； 湖南省高校创新平台开放基金重点项目（11K049）；

本校为第一机构

目的 观察抗癌防移片对4T1小鼠乳腺癌的影响.方法 建立4T1乳腺癌小鼠模型,随机分为空白对照组、模型组、环磷酰胺组和抗癌防移片组,分别给予药物或生理盐水,动态观察给药期间小鼠生活状况.给药4周后处死小鼠,测定小鼠体质量增加百分数,测量剥离瘤体积,计算瘤体积抑制率以及计数肺转移瘤灶个数.结果 与模型组比较,抗癌防移片组小鼠肿瘤生长缓慢,肺转移瘤灶数量明显减少(P＜0.05);与环磷酰胺组比较,抗癌防移片组药物毒副作用小(P＜0.05),生活质量高,但其抑瘤防转移作用不及环磷酰胺(P＜0.05).结论 抗癌防移片能抑制4T1小鼠乳腺癌生长与转移,改善小鼠生存质量.

Objective To observe the effect of Kang＇ai Fangyi Tabelt on 4T1 breast cancer of mice. Methods The mouse model of 4T1 breast cancer was established. The experimental mice were divided into four groups randomly which were called control group, model group, cytoxan group and Kang＇ai Fangyi Tablet group; and then, gave a regular injection of cytoxan, Kang＇ai Fangyi Tabelt or saline to the mice, respectively, except control group. The living condition of mice during administration was observed in a dynamic way. After four weeks, the mice was kil...