期刊论文

Mechanism of Electroacupuncture Quchi(LI 11)-Yanglingquan(GB 34)in Rats with Spasticity of Cerebral Apoplexy

中文

康复学报

2096-0328

2020

30

1

52-57,63

10.3724/SP.J.1329.2020.01011

81673886:国家自然科学基金 2014CB543102:国家重点基础研究发展计划（973计划） 2018JJ2294:湖南省自然科学基金 201862:湖南省中医药科研项目 CX2018B488:湖南省研究生科研创新项目

本校为第一机构

目的:观察电针曲池-阳陵泉对脑卒中痉挛状态(SCA)下SD大鼠神经损伤与肌张力情况、海马区突触超微形态变化、脑源性神经营养因子(BDNF)、酪氨酸蛋白激酶B(TrkB)蛋白及基因表达等变化的影响,揭示电针缓解痉挛的中枢作用机制.方法:将36只SD大鼠通过随机数字表法分为电针组、假手术组、模型组、空白对照组,每组9只.采用改良Zea-Longa线栓法+内囊注射N-甲基-D-天冬氨酸受体(NMDA)法制备脑卒中肢体痉挛大鼠模型,行为学评分确认造模成功后,开始在双侧曲池、阳陵泉行电针治疗,密波,100 Hz,电压20 V,每次30 min,每日1次,持续5 d.行为学检测治疗后的神经功能与肌张力情况,电镜观察海马内突触的超微结构变化...

Objective:The purpose of this study is to analyze the effects of electroacupuncture Quchi(LI 11)-Yanglingquan(GB 34)in Sprague-Dawley(SD)rats with spasticity of cerebral apoplexy(SCA)on the nerve injury,ultrastructural changes in synapses,and brain derived neurotrophic factor(BDNF),tyrosine protein kinase B(TrkB)and receptor gene expression levels in hippocampus,so as to reveal the efficacy and mechanism of electroacupuncture. Methods:A total of thirty-six SD rats were randomly divided into electroacupuncture group,sham operation group,model group and blank group,with nine SD rats in each grou...