Identification of the Active Compounds in the Yi-Fei-San-Jie Formula Using A Comprehensive Strategy Based on Cell Extraction/UPLC-MS/MS, Network Pharmacology, and Molecular Biology Techniques

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Leihao;Luo, Jiamin;Wen, Guiqing;Sun, Lingling;Liu, Wei;...

通讯作者：

Wang, LS;Lin, LZ;Su, WW

作者机构：

[Luo, Jiamin; Hu, Leihao] Guangzhou Univ Chinese Med, Sch Clin Med 1, Guangzhou 510006, Guangdong, Peoples R China.

[Wang, Lisheng; Wen, Guiqing] Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China.

[Lin, Lizhu; Sun, Lingling; Lin, LZ; Hu, Hao; Hu, Leihao] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Oncol Ctr, Guangzhou 510402, Guangdong, Peoples R China.

[Liu, Wei] Guangzhou Univ Chinese Med, Lingnan Med Res Ctr, Guangzhou 510006, Guangdong, Peoples R China.

[Li, Jing] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Wang, LS ; Lin, LZ ] G

[Su, WW ] S

Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China.

Guangzhou Univ Chinese Med, Affiliated Hosp 1, Oncol Ctr, Guangzhou 510402, Guangdong, Peoples R China.

Sun Yat Sen Univ, Guangdong Engn & Technol Res Ctr Qual & Efficacy R, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, Guangzhou 510275, Guangdong, Peoples R China.

语种：

英文

关键词：

Cell extraction;Network pharmacology;UPLC-MS/MS;Yi-Fei-San-Jie formula

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2023

卷：

115

页码：

154843

DOI：

10.1016/j.phymed.2023.154843

基金类别：

Collaborative innovation research and high-level team building of integrated Chinese and Western medicine in the diagnosis and treatment of malignant tumors [2021XK09]; Basic Theoretical Research of Chinese Medicine of Guangzhou University of Chinese Medicine [[2022] -7]; Cooperative Research of High Level Hospital Project (Lung Cancer); National Natural Science Foundation of China [81973775, 2022YFC3500203]; National Key Research and Development Program [2021M700964]; Postdoctoral Science Foundation of China; [82104647]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

BACKGROUND: Chinese herbal formulae has multiple active constituents and targets, and the good clinical response is encouraging more scientists to explore the bio-active ingredients in such complex systems. Yi-Fei-San-Jie formula (YFSJF) is commonly used to treat patients with lung cancer in South China; however, its bio-active ingredients remain unknown. PURPOSE: We investigated the bio-active ingredients of the YFSJF using a novel comprehensive strategy. METHODS: A549 cell extraction coupled with ultra-high performance liquid chromatography-m...

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Identification of the Active Compounds in the Yi-Fei-San-Jie Formula Using A Comprehensive Strategy Based on Cell Extraction/UPLC-MS/MS, Network Pharmacology, and Molecular Biology Techniques

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