Purpose: To investigate the underlying mechanisms by which Astragalus polysaccharide (APS) relieves the reproductive toxicity induced by phenobarbital (PB) treatment in epileptic rats. Methods: Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay kits were used to quantify cell apoptosis in an epileptic rat model. The weight of sex organs and levels of three reproductive hormones, viz, follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, were measured in order to evaluate the effect of APS administration on reproductive ability. Concentration, mo...
