Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells

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成果类型：

期刊论文

作者：

Peng, Qing-Hua;Tong, Ping;Gu, Li-Min;Li, Wen-Jie*

通讯作者：

Li, Wen-Jie

作者机构：

[Peng, Qing-Hua] Hunan Univ Chinese Med, Dept Ophthalmol & Otorhinolaryngol Chinese Med, Changsha 410208, Peoples R China.

[Peng, Qing-Hua] Hunan Key Lab, Changsha 410208, Peoples R China.

[Tong, Ping] Cent S Univ, Xiangya Hosp 2, Dept Ophthalmol, Changsha 410011, Peoples R China.

[Gu, Li-Min] Second Mil Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Shanghai 200438, Peoples R China.

[Li, Wen-Jie] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410013, Peoples R China.

通讯机构：

[Li, Wen-Jie] H

Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410013, Peoples R China.

语种：

英文

关键词：

Apoptosis;Astragalus polysaccharides;ER stress;Metabolic memory;SIRT1;miR-204

期刊：

Bioscience Reports

ISSN：

0144-8463

年：

2020

卷：

期：

页码：

BSR20192121.

DOI：

10.1042/BSR20192121

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

摘要：

Background: 'Metabolic memory' of early hyperglycaemic environment has been frequently suggested in the progression of diabetic retinopathy (DR). Retinal pigment epithelial (RPE) cells are crucial targets for DR initiation following hyperglycaemia. Astragalus polysaccharides (APS) has been long used as a traditional Chinese medicine in treating diabetes. In the present study, the preventive effects and mechanisms of APS on metabolic memory-induced RPE cell death were investigated. Methods: The expressions of miR-204 and SIRT1 were determined by...

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Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells

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