Astragalus polysaccharide ameliorates steroid-induced osteonecrosis of the femoral head by regulating miR-200b-3p-mediated Wnt/β-catenin signaling pathway via inhibiting SP1 expression: Astragalus polysaccharide regulates SONFH via SP1
The authors gratefully acknowledge the financial supports of Provincial Natural Science Foundation of Hunan,Youth Foundation: Mechanism of astragalus polysaccharide ameliorating steroid-induced osteonecrosis of femoral head via regulation of osteocyte autophagy and apoptosis through down-regulating miR-206 (No. 2022JJ40328).
机构署名：
本校为第一且通讯机构
院系归属：
第一中医临床学院
第二中医临床医学院
摘要：
Steroid-induced osteonecrosis of the femoral head (SONFH) is the necrosis of the femur bone caused by prolonged and massive use of corticosteroids. The present study probed into the significance of Astragalus polysaccharide (APS) in SONFH progression. SONFH cell model was constructed using murine long bone osteocyte Y4 (MLO-Y4) cells and then treated with APS. mRNA microarray analysis selected differentially expressed genes between control group and SONFH group. RT-qPCR determined SP1 and miR-200b-3p expression. Levels of SP1, β-catenin, autop...
