Dihydromyricetin affect the pharmacokinetics of triptolide in rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Yang;Guo, Lin;Cai, Hualin;Chen, Lei;Tan, Shenglan;...

通讯作者：

He, Guixia;Yan, Miao

作者机构：

[Yan, Miao; Xiang, Daxiong; Tan, Shenglan; Chen, Lei; Deng, Yang; Li, Huande; Cai, Hualin; Zhang, Bikui; Fang, Pingfei; He, Guixia; Yan, M; Guo, Lin] Cent S Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

[Deng, Yang; He, Guixia] Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China.

[Deng, Yang] Third Hosp Changsha, Dept Pharm, Changsha, Peoples R China.

通讯机构：

[He, GX; Yan, M] C

Cent S Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Dihydromyricetin;LC-MS/MS;interaction;pharmacokinetics;triptolide

期刊：

Xenobiotica

ISSN：

0049-8254

年：

2020

卷：

期：

页码：

332-338

DOI：

10.1080/00498254.2019.1616851

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Abstract 1. Dihydromyricetin (DMY) has anti-tumor and hepatoprotective activities and inhibits the activity of CYP enzymes and P-gp. In this research, we explored the effect of DMY on the pharmacokinetics of triptolide (TP), an anti-tumor Chinese medicine that is mainly metabolized by CYP enzymes and is the substrate of P-gp. 2. Rats were administrated TP (1.2 mg/kg) with and without DMY in different dosage regimens, then a sensitive and reliable LC–MS/MS method was developed and applied to assess the pharmacokinetics of TP. The blood samples...

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Dihydromyricetin affect the pharmacokinetics of triptolide in rats

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