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Underlying mechnism of electroacupuncture for treating detrusor hyperreflexia after suprasacral spinal cord injury through the PACAP-cAMP signaling pathway: 基于PACAP-cAMP信号通路研究电针治疗骶上脊髓损伤后逼尿肌反射亢进型膀胱的效应机制

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成果类型:
期刊论文
作者:
许明;刘琼;邓石峰;刘继生;李亚;...
通讯作者:
Kun AI<&wdkj&>Hong ZHANG
作者机构:
[Ming XU; Qiong LIU; Shi-feng DENG; Ji-sheng LIU; Ya LI; Zi-yuan JIAO; Jing-zhi KUANG; Kun AI; Hong ZHANG] School of Acupuncture-Moxibustion and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China (湖南中医药大学针灸推拿与康复学院, 长沙 410208, 中国)
通讯机构:
[Kun AI; Hong ZHANG] S
School of Acupuncture-Moxibustion and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China (湖南中医药大学针灸推拿与康复学院, 长沙 410208, 中国)
语种:
中文
关键词:
电针;神经源性膀胱;骶上脊髓损伤;尿流动力学;垂体腺苷酸环化酶激活肽;环腺苷酸
关键词(英文):
ELECTROACUPUNCTURE;Neurogenic;bladder;Suprasacral;spinal;cord;injury(SscI);URODYNAMICS;Pituitary;adenylate;cyclase;activating;peptide(PACAP);Cyclic;adenosine;monophosphate(cAMP)
期刊:
世界针灸杂志:英文版
ISSN:
1003-5257
年:
2023
卷:
33
期:
3
页码:
273-281
基金类别:
Supported by National Natural Science Foundation of China:82274666,82205255 Natural Science Foundation of Hunan Province:2022JJ30036,2022JJ40312,20221140301 Research Project of Education Department of Hunan Province:20C1432,21B0369 Discipline of Integrated Traditional Chinese and Western Medicine of Hunan Province:2020ZXYJH23。
机构署名:
本校为第一且通讯机构
院系归属:
针灸推拿与康复学院
摘要:
Objective:To elucidate the underlying mechanism and effect of electroacupuncture(EA)on the neurogenic bladder ...展开更多 Objective:To elucidate the underlying mechanism and effect of electroacupuncture(EA)on the neurogenic bladder following suprasacral spinal cord injury(ssCI).A rat model of detrusor hyperreflexia after SsCI was established to examine the urodynamics,detrusor muscle tissue morphology,the protein and mRNA expression levels of pituitary adenylate cyclase activating peptide(PACAP)and its receptor PAC1R,and cyclic adenosine monoph...
摘要(英文):
To elucidate the underlying mechanism and effect of electroacupuncture (EA) on the neurogenic bladder following suprasacral spinal cord injury (SSCI). A rat model of detrusor hyperreflexia after SSCI was established to examine the urodynamics, detrusor muscle tissue morphology, the protein and mRNA expression levels of pituitary adenylate cyclase activating peptide (PACAP) and its receptor PAC1R, and cyclic adenosine monophosphate (cAMP) content in the detrusor muscle with a focus on the PACAP-cAMP signaling pathway. A total of 72 female SD rat...

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