Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yu, Yipin;Yi, Qiong;Yang, Chenglong;Song, Xudong;Tan, Duoting;...

通讯作者：

Liang, H;Sun, X

作者机构：

[Song, Xudong; Yu, Yipin; Tan, Duoting] Hunan Univ Chinese Med, Inst TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

[Yi, Qiong] Hunan Univ Chinese Med, Hosp 1, ICU Dept, Changsha 410021, Hunan, Peoples R China.

[Yang, Chenglong] Hunan Univ Chinese Med, Hosp 1, Cardiovasc Dept, Changsha 410021, Hunan, Peoples R China.

[Liang, H; Peng, Qinghua; Liang, Hao] Hunan Univ Chinese Med, Hunan Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

[Sun, X; Sun, Xiang] Changsha Hosp Chinese Med, Cardiol Dept, Changsha 410001, Hunan, Peoples R China.

通讯机构：

[Liang, H ] H

[Sun, X ] C

Hunan Univ Chinese Med, Hunan Prov Key Lab TCM Diagnost, Changsha 410208, Hunan, Peoples R China.

Changsha Hosp Chinese Med, Cardiol Dept, Changsha 410001, Hunan, Peoples R China.

语种：

英文

关键词：

biomarker;diuretic resistance;heart failure;metabolomic

期刊：

REVIEWS IN CARDIOVASCULAR MEDICINE

ISSN：

1530-6550

年：

2025

卷：

期：

页码：

27001

DOI：

10.31083/RCM27001

基金类别：

Natural Science Foundation of Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

第一中医临床学院

摘要：

BACKGROUND: Diuretic resistance (DR) is characterized by insufficient fluid and sodium excretion enhancement despite maximum loop diuretic doses, indicating a phenotype of refractory heart failure (HF). Recently, metabolomics has emerged as a crucial tool for diagnosing and understanding the pathogenesis of various diseases. This study aimed to differentiate diuretic-resistant patients from non-resistant HF to identify biomarkers linked to the emergence of DR. METHODS: Serum samples from HF patients, both with and without DR, were subjected to non-targeted metabolomic analysis using liquid chr...

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Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure

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