A bi-functional fluorescent probe for visualized and rapid natural drug screening via GSTs activity monitoring

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Qin, Yan*;Peng, Caiyun;Yang, Wei;Fan, Jialong;Sheng, Wen-Bing;...

通讯作者：

Qin, Yan;Wang, W;Liu, B

作者机构：

[Qin, Yan; Peng, Caiyun; Wang, Wei; Jiang, Sai; Yi, Pan; Sheng, Wen-Bing; Qiu, Yixing; Yu, Huanghe; Qin, Y] Hunan Univ Chinese Med, Sch Pharmay, TCM, Changsha 410208, Hunan, Peoples R China.

[Qin, Yan; Peng, Caiyun; Wang, Wei; Jiang, Sai; Yi, Pan; Sheng, Wen-Bing; Qiu, Yixing; Yu, Huanghe; Qin, Y] Hunan Univ Chinese Med, Sch Pharmay, Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.

[Liu, B; Fan, Jialong; Liu, Bin] Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.

[Yang, Wei] Hunan Womens Univ, Coll Foreign Languages, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Liu, B ; Wang, W ; Qin, Y] H

Hunan Univ Chinese Med, Sch Pharmay, TCM, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Pharmay, Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.

Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

Glutathione S-transferases (GSTs);Bi-functional fluorescence probe;Natural drug screening;GSTs inhibitor

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2021

卷：

328

页码：

129047

DOI：

10.1016/j.snb.2020.129047

基金类别：

Hunan Municipal Administration of Traditional Chinese Medicine#&#&#201989 Hunan Department of Science and Technology#&#&#2020JJ5421 Natural Science Foundation of China#&#&#81673579#&#&#81874369#&#&#82003931 Ministry of Science and Technology#&#&#2018YFC1707902#&#&#2018FY100703 Hunan Department of Science and Technology#&#&#2018WK2081#&#&#2018SK2110

机构署名：

本校为第一且通讯机构

摘要：

Glutathione S-transferase (GSTs), as an important target for drug screening, is closely associated with physiological and pathological process regulation. Hence, effective monitoring of GSTs activity is benificial for GSTs-induced diseases diagnosis and therapeutic drugs discovery. Resorufin-typed probes with high sensitivity, excellent selectivity, and low cytotoxicity have become a powerful tool for target monitoring. In this study, a bifunctional fluorescent probe, resorufin-typed probe (RP) with resorufin as a fluorophore was designed as the GSTs substrate and drug screening tool. GSTs can...

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A bi-functional fluorescent probe for visualized and rapid natural drug screening via GSTs activity monitoring

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