期刊论文

Study of active principle region of YangxinTongmai Formula effects on the acute myocardial infarction in rats with MSCs transplantation

中文

重庆医学

1671-8348

2015

44

34

4762-4764,4767

10.3969/j.issn.1671-8348.2015.34.004

81102595:国家自然科学基金 30772696:国家自然科学基金

本校为其他机构

目的 探讨养心通脉有效部位方(apr-YTF)对急性梗死心肌实施骨髓间充质干细胞(MSCs)移植促修复的影响.方法 将造模成功的AMI大鼠分为模型对照组、空白对照组、阳性对照组[重组人粒细胞集落刺激因子(rhG-CSF)]和实验观察组(apr-YTF),分别给予MSCs以及相应药物心肌注射,PcLab生物医学信号采集处理系统测定在体心功能,免疫组织化学检测缝隙连接蛋白43(Cx43),RT-PCR检测心脏早期发育基因NKx2.5.结果 实验观察组动物的心功能恢复最好;心肌细胞Cx43阳性着色颗粒呈分散样改变,主要分布于端端连接的闰盘区域和侧侧连接的胞膜上,实验观察组的IOD值最高;各组NKx2.5均有一定水平的表达,实验观察组表达最强,而...

Objective To investigate the effect of active principle region of YangxinTongmai Formuta（apr-YTF） on the re- covery of bone marrow mesenchymal stem cells（MSCs） transplantation in acute myocardial infarction （AMI）. Methods AM] rats were divided into model control group, blank control group, positive control group [recombinant huritan granulocyte colony stimuLa- ting factor （rhG-CSF）] and experimental observation group（apr-YTF）. MSCs and the corresponding drugs were administered re- positive staining particles were mainly distributed in...