Panax notoginseng saponins prevent colitis-associated colorectal cancer development:the role of gut microbiota

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成果类型：

期刊论文

作者：

CHEN Ling;CHEN Man-Yun;SHAO Li;ZHANG Wei;RAO Tai;...

通讯作者：

Huang, WH

作者机构：

Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha 410008, Peoples R China.

Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.

Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, Dept Pharmacognosy, Changsha 410128, Peoples R China.

通讯机构：

[Huang, WH ] C

Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.

Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

语种：

英文

关键词：

Panax notoginseng saponins;Gut microbiota;Colorectal cancer;Ginsenosides;16S rRNA gene sequencing

期刊：

中国天然药物

ISSN：

2095-6975

年：

2020

卷：

期：

页码：

500-507

DOI：

10.1016/S1875-5364(20)30060-1

基金类别：

This work was supported by the National Natural Scientific Foundation of China (No. 81903784), Key Research and Development Plan of Hunan Province (No. 2018sk2129), Hunan Provincial Natural Science Foundation of China (No. 2020JJ4878)

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Gut microbiota dysbiosis is a risk factor for colorectal cancer (CRC) in inflammatory bowel disease (IBD). In this study, the effects of Panax notoginseng saponins (PNS) on colitis-associated CRC progression were evaluated on an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. In vivo, PNS significantly relieved AOM/DSS-induced colon tumorigenesis and development by reducing the disease activity index (DAI) scores and colon tumor load. The 16S rRNA data of fecal samples showed that the microbiome community was obviously destructed, while PNS could recover the richness and diversity...

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