Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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成果类型：

期刊论文

作者：

Liu, Jun;Li, Dan-Dan;Dong, Wei;Liu, Yu-Qi;Wu, Yang;...

通讯作者：

Wang, Yong-Yan;Chen, Yun-Dai;Wang, Zhong

作者机构：

[Li, Bing; Yu, Ya-Nan; Liu, Jun; Wang, Yong-Yan; Dang, Hai-Xia; Wang, Zhong] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China.

[Li, Dan-Dan; Chen, Yun-Dai; Dong, Wei; Liu, Yu-Qi] Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China.

[Wu, Yang; Tang, Da-Xuan] Beijing Univ Chinese Med, Dongfang Hosp Affiliated, Dept Cardiol, Beijing, Peoples R China.

[Zhang, Fu-Chun; Qiu, Meng] Peking Univ Third Hosp, Dept Geratol, Beijing, Peoples R China.

[He, Jing-Yu; Hua, Qi] Capital Med Univ, Xuan Wu Hosp, Dept Cardiol, Beijing, Peoples R China.

通讯机构：

[Wang, Zhong; Wang, Yong-Yan] I

[Chen, Yun-Dai] D

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

语种：

英文

期刊：

信号转导与靶向治疗

ISSN：

2095-9907

年：

2021

卷：

期：

页码：

3009-3018

DOI：

10.1038/s41392-021-00741-x

基金类别：

We thank all the staff of the 31 clinical centers for their contributions to the investigation of the trial. This work was funded by China National Science and Technology Major Project for “Significant New Drugs Development” (2011ZX09304-07), National Natural Science Foundation of China (81673833), and China Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ0908029).

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本校为其他机构

院系归属：

第二中医临床医学院

摘要：

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart disease. Here, in an adaptive, 31-center, randomized, double-blind trial involving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI), a kind of polypharmacological drug with high quality control, or placebo (0.9% saline), with 76-day following-up, we firstly confirmed that DHI could increase the ...

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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