PVAT targets VSMCs to regulate vascular remodelling: angel or demon

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Yin-Yu;Shi, Ya-Ning;Zhu, Neng;Zhao, Tan-Jun;Guo, Yi-Jie;...

通讯作者：

Qin, Li;Dai, Ai-Guo

作者机构：

[Zhang, Yin-Yu; Shi, Ya-Ning; Guo, Yi-Jie; Liao, Duan-Fang; Zhao, Tan-Jun; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Dept Pharmacol, Changsha, Peoples R China.

[Zhang, Yin-Yu; Shi, Ya-Ning; Guo, Yi-Jie; Liao, Duan-Fang; Zhao, Tan-Jun; Qin, Li] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.

[Dai, Ai-Guo] Hunan Univ Chinese Med, Med Sch, Dept Resp Dis, Changsha, Peoples R China.

[Dai, Ai-Guo] Hunan Univ Chinese Med, Med Sch, 300 Xueshi Rd, Changsha 410208, Peoples R China.

通讯机构：

[Qin, Li; Dai, Ai-Guo] H

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Med Sch, 300 Xueshi Rd, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Perivascular adipose tissue;vascular smooth muscle cells;adipokines;atherosclerosis;hypertension;pulmonary arterial hypertension

期刊：

Journal of Drug Targeting

ISSN：

1061-186X

年：

2021

卷：

期：

页码：

467-475

DOI：

10.1080/1061186X.2020.1859515

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973668, 81774130, 81670268, 81603600]; Science Foundation for Distinguished Young Scholars of Hunan ProvinceNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [2018JJ1018]; Hunan Provincial Key Discipline of Pharmaceutical Science

机构署名：

本校为第一且通讯机构

院系归属：

医学院

第一中医临床学院

药学院

摘要：

Vascular remodelling refers to abnormal changes in the structure and function of blood vessel walls caused by injury, and is the main pathological basis of cardiovascular diseases such as atherosclerosis, hypertension, and pulmonary hypertension. Among them, the neointimal hyperplasia caused by abnormal proliferation of vascular smooth muscle cells (VSMCs) plays a key role in the pathogenesis of vascular remodelling. Perivascular adipose tissue (PVAT) can release vasoactive substances to target VSMCs and regulate the pathological process of vascular remodelling. Specifically, PVAT can promote ...

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PVAT targets VSMCs to regulate vascular remodelling: angel or demon

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