期刊论文

Research Advances in Structural Modification and Antitumor Activity of Celastrol

中文

化学试剂

0258-3283

2024

46

1

17-25

10.13822/j.cnki.hxsj.2023.0616

湖南省自然科学基金项目(2022JJ80089) 湖南中医药大学2022年大学生创新创业训练计划项目(221) 2023年度湖南省大学生创新创业训练计划一般项目(湘教通〔2023〕237号-S202310541073)。

本校为第一机构

雷公藤红素是一种来源于药用植物雷公藤(Tripterygium wilfordii Hook.f.)的五环三萜类天然活性产物,具有显著而广泛的抗肿瘤活性,然而,水溶性差、毒副作用强等缺点限制了其转化成为临床抗肿瘤药物。为...展开更多 雷公藤红素是一种来源于药用植物雷公藤(Tripterygium wilfordii Hook.f.)的五环三萜类天然活性产物,具有显著而广泛的抗肿瘤活性,然而,水溶性差、毒副作用强等缺点限制了其转化成为临床抗肿瘤药物。为此,通过结构修饰,改善其临床应用的局限性成为该研究领域的热点。迄今,针对其进行的结构修饰主要集中于A环C-2、C-3位,B环的C-6位及E环的28位,主要有酯化、酰胺化及引入药效基团等修饰...

Celastrol,a kind of natural active product of pentacyclic triterpenes,roots in medicinal plant Tripterygium wilfordii Hook.f.It possesses significant and extensive antitumor activity.However,its conversion into clinical antitumor drugs is limited by poor water solubilit...MORE Celastrol,a kind of natural active product of pentacyclic triterpenes,roots in medicinal plant Tripterygium wilfordii Hook.f.It possesses significant and extensive antitumor activity.However,its conversion into clinical antitumor drugs is limited by poor water solubility,strong toxic side effects and other disadvantages....