期刊论文

Tanowitz, Herbert B.

英文

American Journal of Pathology

0002-9440

2013

182

3

886-894

10.1016/j.ajpath.2012.11.027

NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [EL-112099]; Einstein Nathan Shock Center's Cellular and Tissue Aging Core [P30AG038072, R01-DK55758, P01-DK088761, AI-76248]; FAPEMIGMinas Gerais State Research Foundation (FAPEMIG); CNPqNational Council for Scientific and Technological Development (CNPq) [DK-033823, DK087776, NS069577, CA-129003]; Einstein Diabetes Research Center [DK020541]; Juvenile Diabetes Association [JDRF-3-2008-130]; National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA013330]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, 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P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330, P30CA013330] Funding Source: NIH RePORTER; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R21HL112099, R21HL112099] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI076248, R01AI076248, R01AI076248, R01AI076248, R01AI076248, R01AI076248] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [P60DK020541, P60DK020541, P30DK020541, R37DK033823, P30DK026687, 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K01DK087776, P30DK026687, P30DK026687, P60DK020541, P60DK020541, P30DK026687, P60DK020541, P01DK088761, P60DK020541, R37DK033823, R01DK033823, P60DK020541, P01DK088761, P60DK020541, P60DK020541, R37DK033823, K01DK087776, P60DK020541, P60DK020541, P30DK026687, P30DK026687, R01DK055758, P30DK026687, R01DK055758, P60DK020541, P30DK026687, P30DK020541, P30DK026687, R01DK033823, P30DK026687, P60DK020541, P60DK020541, P60DK020541, P60DK020541, P30DK020541, P30DK026687, P30DK026687, P30DK026687, P60DK020541, P30DK020541, P30DK026687, K01DK087776, P30DK020541, P60DK020541, P30DK026687, P30DK026687, P60DK020541, P60DK020541, P60DK020541, P30DK020541, P01DK088761, P30DK020541, P30DK026687, P30DK026687, P60DK020541, R37DK033823, P30DK026687, P60DK020541, P60DK020541, P30DK026687] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS069577, R01NS069577, R01NS069577, R01NS069577, R01NS069577, R01NS069577] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072, P30AG038072] Funding Source: NIH RePORTER

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Chagas disease, caused by Trypanosoma cruzi, is an important cause of morbidity and mortality primarily resulting from cardiac dysfunction, although T. cruziin fection results in inflammation and cell destruction in many organs. We found that T. cruzi (Brazil strain) infection of mice results in pancreatic inflammation and parasitism within pancreatic beta-cells with apparent sparing of a cells and leads to the disruption of pancreatic islet architecture, beta-cell dysfunction, and surprisingly, hypoglycemia. Blood glucose and insulin levels were reduced in infected mice during acute infection...