Alterations in Glucose Homeostasis in a Murine Model of Chagas Disease

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成果类型：

期刊论文

作者：

Nagajyothi, Fnu;Kuliawat, Regina;Kusminski, Christine M.;Machado, Fabiana S.;Desruisseaux, Mahalia S.;...

通讯作者：

Tanowitz, HB

作者机构：

[Weiss, Louis M.; Desruisseaux, Mahalia S.; Zhao, Dazhi; Factor, Stephen M.; Tanowitz, Herbert B.; Nagajyothi, Fnu; Huang, Huan] Albert Einstein Coll Med, Dept Pathol, Div Parasitol & Trop Med, Bronx, NY 10461 USA.

[Kuliawat, Regina] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA.

[Weiss, Louis M.; Desruisseaux, Mahalia S.; Tanowitz, Herbert B.; Singh, Rajat; Schwartz, Gary J.; Pessin, Jeffrey E.] Albert Einstein Coll Med, Dept Med, Div Infect Dis, Bronx, NY 10461 USA.

[Weiss, Louis M.; Desruisseaux, Mahalia S.; Tanowitz, Herbert B.; Singh, Rajat; Schwartz, Gary J.; Pessin, Jeffrey E.] Albert Einstein Coll Med, Dept Med, Div Endocrinol, Bronx, NY 10461 USA.

[Singh, Rajat; Schwartz, Gary J.; Pessin, Jeffrey E.] Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10461 USA.

通讯机构：

[Tanowitz, HB ] A

Albert Einstein Coll Med, Dept Pathol, 1300 Morris Pk Ave, Bronx, NY 10461 USA.

语种：

英文

期刊：

AMERICAN JOURNAL OF PATHOLOGY

ISSN：

0002-9440

年：

2013

卷：

182

期：

页码：

886-894

DOI：

10.1016/j.ajpath.2012.11.027

基金类别：

NIH [EL-112099]; Einstein Nathan Shock Center's Cellular and Tissue Aging Core [P30AG038072, R01-DK55758, P01-DK088761, AI-76248]; FAPEMIG; CNPq [DK-033823, DK087776, NS069577, CA-129003]; Einstein Diabetes Research Center [DK020541]; Juvenile Diabetes Association [JDRF-3-2008-130]; National Cancer Institute [P30CA013330]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Chagas disease, caused by Trypanosoma cruzi, is an important cause of morbidity and mortality primarily resulting from cardiac dysfunction, although T. cruziin fection results in inflammation and cell destruction in many organs. We found that T. cruzi (Brazil strain) infection of mice results in pancreatic inflammation and parasitism within pancreatic beta-cells with apparent sparing of a cells and leads to the disruption of pancreatic islet architecture, beta-cell dysfunction, and surprisingly, hypoglycemia. Blood glucose and insulin levels were reduced in infected mice during acute infection...

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Alterations in Glucose Homeostasis in a Murine Model of Chagas Disease

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