Objective: To study the effect of sandalwood essential oil on isolated ileum smooth muscle of guinea pigs and the small intestine movement function of mice. Methods: We used the experiment method of isolating ileum smooth muscle of guinea pigs and intestine propulsion of carbon ink in mice. We constructed the models of healthy mice, neostigminetrested mice and adrenaline-loaded mice. Results: Sandalwood essential oil had an inhibitory effect on the spontaneous movement of guinea pigs isolated ileum and an antagonistic action on intestinal spasm caused by acetylcholine, histamine and barium chl...