期刊论文

Effect of Qingre Jiedu Huazhuo Tablets on Inflammatory of Rats Models of Fatty Liver Disease

中文

中华中医药学刊

1673-7717

2016

34

3

744-746

10.13193/j.issn.1673-7717.2016.03.069

本校为第一机构

目的:研究清热解毒化浊片对脂肪性肝病大鼠炎性损伤的影响.方法:采用高脂饮食、酒精灌胃建立脂肪性肝病大鼠模型.模型成功后,随机分为清热解毒化浊片组、非诺贝特组、模型组和正常组4组,经治疗30天后观察肝组织病理学改变,采用比色法检测血清甘油三酯(TG)、总胆固醇(TCHO)、谷丙转氨酶(ALT)、谷草转氨酶(AST)活性,ELISA法检测血清肿瘤坏死因子α(TNF-α)、白介素10(IL-10)和脂联素(ADP)的表达情况.结果:光镜下观察,清热解毒化浊片组大鼠肝组织脂肪蓄积、炎性浸润情况明显改善.与正常组比较,模型组血清TG、TCHO、ALT、AST、TNF-α明显升高(P＜0.01,P＜0.05),血清ADP明显降低(P＜0.01).与模型组比...

Objective： To study the effect of Qingre Jiedu Huazhuo Tablets on the inflammatory of rats models of fatty liver disease. Method： The rat liver inflammation model was established by mixed high amounts of sugars,fats and water.The rats were randomly divided into 4 groups. Qingre Jiedu Huazhuo Tablets were used to treat liver inflammatory model rats for 30 days. The contents of blood serum alanine transaminase（ ALT）,aspartate transaminase（ AST）,triglyceride（ TG） and total cholesterin（ TC） were measured by colorimetry and tumor necrosis ...