The effects of astragaloside IV on gut microbiota and serum metabolism in a mice model of intracerebral hemorrhage

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成果类型：

期刊论文

作者：

Li, Zhilin;Hu, En;Zheng, Fei;Wang, Song;Zhang, Wei;...

通讯作者：

Huang, Qing;Wang, Y

作者机构：

[Wang, Yang; Luo, Jiekun; Hu, En; Tang, Tao; Li, Zhilin] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha 410008, Peoples R China.

[Wang, Yang; Huang, Qing; Huang, Q; Luo, Jiekun; Hu, En; Wang, Y; Tang, Tao; Wang, Song; Li, Zhilin] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

[Wang, Yang; Luo, Jiekun; Hu, En; Tang, Tao] Cent South Univ, Xiangya Hosp, Changsha 330004, Jiangxi, Peoples R China.

[Zhang, Wei; Zheng, Fei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Peoples R China.

[Huang, Qing; Wang, Song] Cent South Univ, Xiangya Hosp, Stroke Ctr, Dept Neurol, Changsha 410008, Peoples R China.

通讯机构：

[Huang, Q; Wang, Y ] C

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.

语种：

英文

关键词：

Astragaloside IV;Gut microbiota;Intestinal barrier;Intracerebral hemorrhage;Lipopolysaccharide;Metabolism

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2023

卷：

121

页码：

155086

DOI：

10.1016/j.phymed.2023.155086

基金类别：

National Natural Science Foundation of China [82174259, 82271365]; Hunan TCM Scientific Research Program [2021032]; Hunan Provincial Key Research and Development Program [2022SK2015]; Natural Science Foundation of Hunan Province [2023JJ30466]; National Science Foundation for Postdoctoral Scientists of China [2022M711130]; Excellent youth funding of Hunan Provincial Education Department [22B0365]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

BACKGROUND: Astragaloside IV (AS-IV) is the main active component of "Astragalus membranaceus (Fisch.) Bunge, a synonym of Astragalus propinquus Schischkin (Fabaceae)", which demonstrated to be useful for the treatment of intracerebral hemorrhage (ICH). However, due to the low bioavailability and barrier permeability of AS-IV, the gut microbiota may be an important key regulator for AS-IV to work. OBJECTIVE: To explore the influences of gut microbiota on the effects of AS-IV on ICH. METHODS: Mice were randomly divided into five groups: sham, IC...

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The effects of astragaloside IV on gut microbiota and serum metabolism in a mice model of intracerebral hemorrhage

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