期刊论文

Effect of Bufei decoction on the expression of IFN-γand IL-4 in serum of rats with chronic obstructive pulmonary disease and emphysema

中文

陕西中医

1000-7369

2019

40

11

1491-1494

10.3969/j.issn.1000-7369.2019.11.001

国家自然科学基金资助面上项目(81473564)。

本校为第一机构

目的:通过建立慢性阻塞性肺疾病(COPD)肺气肿大鼠模型,观察补肺汤对慢性阻塞性肺疾病肺气肿模型大鼠肺组织病理学及血清中IFN-γ、IL-4表达水平的影响,探讨补肺汤的治疗作用及可能的作用机制.方法:将40只清洁级健康SD大鼠,随机分为四组,每组各10只.空白对照组、模型组、西药对照组(脾氨肽组)、中药治疗组(补肺汤组).除空白对照组以外其余各组均予以气道内注射脂多糖联合烟熏的方法制作C O PD肺气肿动物模型,空白对照组与此同时在气道内注射等量生理盐水,空白对照组不予以烟熏.造模结束后,分别给予生理盐水及相应药物灌胃,2次/d,连续给药14 d.第15天开始将大鼠处死,取肺组织观察其病理学变化,用E...

Objective:To observe the effect of Bufei decoction on lung histopathology and serum IFN-γand IL-4 expression in rats with chronic obstructive pulmonary disease(COPD)and emphysema,and to explore the therapeutic effect and possible mechanism of Bufei decoction on COPD emphysema.Methods:40 SD healthy rats were randomly divided into 4 groups with 10 rats in each group.Blank control group,model control group,western medicine control group,traditional Chinese medicine treatment group.In addition to the blank control group,all the other groups were g...