期刊论文

中文

陕西中医

1000-7369

2020

41

6

724-727

10.3969/j.issn.1000-7369.2020.06.007

湖南省研究生科研创新项目(2018CX27) 华润三九集团横向合作项目(5001/0153)。

本校为第一机构

目的:以饮食失节法、耗气破气法、劳倦过度法多因素复合建立脾气虚证大鼠模型,并从大鼠的体重、肛温、血清中SOD活性和MDA含量的变化方面探讨颗粒剂四君子的影响.方法:将 50只大鼠随机分为正常组、模型组、四君子汤组、传统四君子膏组、颗粒四君子膏组,每组 10只.采用边造模边给药的方法,隔日电子天平称取大鼠重量,数字温度计检测大鼠肛温,28d 后处死大鼠,用ELISA 法测定其血清中超氧化物歧化酶(SOD)和丙二醛(MDA)水平.结果:与正常组相比,模型组大鼠的体重、肛温、血清SOD活性均下降,MDA含量增多(P＜0.05).经灌胃四君子制剂药物后,大鼠上述指标均有所恢复,与模型组相比,差异有统计学意义(P＜0.0...

Objective:To establish the rat model of Piqi Xu syndrome with dietary loss of control,energy consumption and excessive fatigue,and to explore the effects of Sijun Zi on body weight,anal temperature,SOD activity and MDA content in serum.Methods:50 rats were randomly divided into normal group,model group,Sijun Zi decoction group,traditional Sijun Zi paste group and granule Sijun Zi paste group,with 10 rats in each group.The rats were weighed with an electronic balance on the next day,and the anal temperature was measured with a digital thermometer.After 28 days,the rats were sacrificed,and their...