期刊论文

Influence of Qiweibaizhu Powder on the Serum IFN- γ and TNF-α Levels of Suckling Mice Infected with Human Rotavirus (HRV)

中文

中国中医药信息杂志

1005-5304

2005

12

3

36-37

10.3969/j.issn.1005-5304.2005.03.018

99JJY20037:湖南省自然科学基金 A0058:湖南省教育厅科学研究项目

本校为其他机构

目的观察七味白术散对人轮状病毒(HRV)感染乳鼠血清干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)的影响,探讨七味白术散治疗HRV感染的作用机制.方法NIH乳鼠经口建立感染模型,按窝随机分为3组,并分别灌服生理盐水(NS)、七味白术散、病毒唑,正常组灌服NS,连续7 d.采用ELISA法检测HRV感染乳鼠血清IFN-γ、TNF-α.结果七味白术散组血清IFN-γ高于模型组,TNF-α低于模型组(P＜0.05).结论七味白术散能提高HRV感染乳鼠血清IFN-γ,下调血清TNF-α,显示一种新的免疫调节效应.

Objective To study the influence of Qiweibaizhu Powder on the serum IFN-γ and TNF-α levels of suckling mice infected with HRV and to explore the mechanism of Qiweibaizhu Powder in the treatment of HRV infection. Methods The model of NIH suckling mice infected with HRV orally were established and were randomly divided into 3 groups by home. The normal control group was treated with NS, and the other groups were treated with NS, Qiweibaizhu Powder, Ribavirin respectively for 7 days. The serum IFN-γand TNF-α levels of suckling mice infected wi...