Cyclocarya paliurus leaves alleviate hyperuricemic nephropathy via modulation of purine metabolism, antiinflammation, and antifibrosis

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成果类型：

期刊论文

作者：

Gui, Rui;Wang, Yi-Kun;Wu, Jian-Ping;Deng, Gui-Ming;Cheng, Fei;...

作者机构：

[Gui, Rui; Zhang, Wei; Wu, Jian-Ping; Wang, Yi-Kun; Wei, Xi -Fan; Wang, Wen-Xuan; Xu, Kang-Ping] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China.

[Zhu, Gang-Zhi; He, Xiao-Ai] Cent South Univ, Xiangya Sch Med, Dept Pharm, Affiliated HaiKou Hosp, Haikou 570100, Peoples R China.

[Wang, Yi-Kun] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Peoples R China.

[Ren, Wei-Qiong; Deng, Gui-Ming; Long, Hong-Ping; Xu, Kang-Ping] Hunan Univ Chinese Med, Hosp 1, Changsha 410208, Peoples R China.

[Cheng, Fei; Zeng, Hong-Liang] Hunan Acad Chinese Med, Inst Chinese Mat Med, Changsha 410013, Peoples R China.

语种：

英文

关键词：

Cyclocarya paliurus;Hyperuricemic nephropathy;Modulation of purine metabolism;Antiinflammation;Antifibrosis

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2023

卷：

103

页码：

105485

DOI：

10.1016/j.jff.2023.105485

基金类别：

Hainan Key Research Project [ZDYF2020213, ZDYF2020171]; Hunan Key Research Project [2022SK2031]; Hunan Natural Science Foundation [2022JJ30788]; Hunan Province Scientific Research Program of Traditional Chinese Medicine [C2022041, 2021171]; Key Project of Changsha Science and Technology Plan [kh2201060]; Central South University postgraduate independent exploration and innovation project [2021zzts0995]; Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University

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本校为其他机构

院系归属：

第一中医临床学院

摘要：

Cyclocarya paliurus, as an important edible and medicinal plant, its effects and mechanisms on hyperuricemic nephropathy remain unclear. Herein, we investigated the hypouricemic and nephroprotective effects of the water extracts of C. paliurus leaves (CPE) in a hyperuricemic nephropathy rat model induced by adenine and ethambutol. The results showed that CPE could significantly decrease plasma uric acid (PUA) and urea nitrogen (PUN), as well as reduce renal fibrosis in the hyperuricemic nephropathy rat model. Plasma metabolomics indicated that CPE improved the disordered arachidonic acid metab...

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Cyclocarya paliurus leaves alleviate hyperuricemic nephropathy via modulation of purine metabolism, antiinflammation, and antifibrosis

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