Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Mi, Yilin;Yi, Nanxing;Xu, Xiaotong;Zeng, Fan;Li, Naping;...

通讯作者：

Gaoyan Kuang<&wdkj&>Min Lu

作者机构：

[Mi, Yilin; Gong, Zhixian; Kuang, Gaoyan; Xu, Xiaotong; Yan, Ke; Zeng, Fan; Li, Naping; Lu, Min; Yi, Nanxing] Hunan Univ Chinese Med, Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Mi, Yilin; Xu, Xiaotong; Zeng, Fan; Yi, Nanxing] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Tan, Xuyi] Hunan Acad Chinese Med Sci, Affiliated Hosp, Changsha 410006, Hunan, Peoples R China.

通讯机构：

[Gaoyan Kuang; Min Lu] T

The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China

语种：

英文

期刊：

Food & Function

ISSN：

2042-6496

年：

2023

卷：

期：

页码：

4065-4077

DOI：

10.1039/d3fo00775h

基金类别：

National Natural Science Foundation of China [82174414, 82274543]; construction project of the National Famous and Old Chinese Medicine Experts Inheritance Studio of the National Administration of Traditional Chinese Medicine (Renjiao Letter (2022) [22JBZ026]; Hunan Provincial Administration of Traditional Chinese Medicine's "14th Five-Year Plan" first batch of TCM leading talent training projects and 2022 Annual discipline construction "Jiebang Guashuai" project of Hunan University of Chinese Medicine; [75]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and inflammation as the main pathological manifestations. This study aims to investigate the protective effect of prebiotics in post-traumatic osteoarthritic (PTOA) mice by modulating the gut barrier and fecal metabolomics. The results suggested that cartilage degeneration, osteophyte formation and inflammation were significantly reduced by prebiotics in PTOA mice. In addition, the gut barrier was protected by the increased expression of tight ...

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Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

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