期刊论文

中文

湖南中医药大学学报

1674-070X

2011

31

11

19-23

10.3969/j.issn.1674-070X.2011.11.006.019.05

本校为第一机构

目的 评价黄葵素(huangkuisu,HKS)抗结核分枝杆菌的活性.方法 ①采用人型结核分枝杆菌标准菌株(H37RV)、多药耐药结核菌株,分别接种于含有不同浓度黄葵素、空白对照和阳性药物的结核菌培养基,观察结核分枝杆菌的生长情况,评价其体外抗菌活性.②尾静脉注射一定数量的结核分枝杆菌标准株H37Rv和耐药株菌液,建立小鼠结核分枝杆菌感染模型.随机将模型小鼠分成利福平治疗组、黄葵素治疗组,持续治疗6周,对照组给予生理盐水治疗.以各组小鼠的肺组织和脾组织病理变化、组织荷菌量,比较各组治疗效果,评价其体内抗菌活性.结果 ①模型组菌落生长情况正常,黄葵素(100 mg/mL)、利福平(5 mg/mL)组结核分枝杆菌...

Objective To evaluate the antituberculous activities of Huangkuisu（HKS）.Methods ①Standard human strains of mycobacterium tuberculosis（H37RV） and multi-drug resistant TB strains were inoculated in different concentrations of HKS,blank control and positive TB drug culture medium to observe the growth of mycobacterium tuberculosis and evaluate the antibacterial activity in vitro.②Certain number of standard strains of Mycobacterium tuberculosis H37Rv and drug-resistant strains were injected into the tail vein to establish a mouse model of myc...