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Investigation into actions of Xiebai and Zengye decoction on cough sensitivity, airway inflammation and gut microbiota in the rat model of post-infectious cough

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成果类型:
期刊论文
作者:
Luo, Jing;Deng, Yijue;Ding, Yi;Zhang, Ying;Tan, Min;...
通讯作者:
Tang, CG;Wang, MQ
作者机构:
[Tang, Chenguang; Xu, Guangning; Zhang, Ying; Luo, Jing; Tan, Min; Lin, Huining] Shenzhen Qianhai Shekou Free Trade Zone Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.
[Deng, Yijue; Wang, MQ; Wang, Mengqing; Luo, Jing] Hunan Univ Chinese Med, Dept Paediat, Hosp 1, Changsha, Peoples R China.
[Ding, Yi] Changsha Social Work Coll, Sch Rehabil, Changsha, Peoples R China.
通讯机构:
[Tang, CG ] S
[Wang, MQ ] H
Shenzhen Qianhai Shekou Free Trade Zone Hosp, Dept Tradit Chinese Med, Shenzhen, Peoples R China.
Hunan Univ Chinese Med, Dept Paediat, Hosp 1, Changsha, Peoples R China.
语种:
英文
关键词:
Post-infectious cough;Xiebai and Zengye decoction;Fecal water content;Cough sensitivity;Inflammation;Gut microbiota
期刊:
Heliyon
ISSN:
2405-8440
年:
2023
卷:
9
期:
12
页码:
e22782
基金类别:
National Natural Science Foundation of China [81774368]; Shenzhen Nanshan District Education (Health) Science and Technology Project [NS2023061]; Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine [4901-020000200207]; Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine [20241256]; Shenzhen Key Discipline Construction Funding Project of Traditional Chinese Medicine; Hunan Provincial Natural Science Foundation Project [2023JJ60260]
机构署名:
本校为其他机构
院系归属:
第一中医临床学院
摘要:
This work was undertaken to observe therapeutic effect of Xiebai and Zengye (XBZY) decoction on post-infectious cough (PIC) in rats, as well as its effect on gut microbiota and the exploration of the intestinal microecological mechanisms of XBZY decoction in the treatment of PIC. Using a random number table, the rats that were successfully modelled were assigned to the PIC, XBZY group (14.8g/kg/d), and montelukast sodium treatment (MAS) group (1mg/kg/d). The cough sensitivity of rats and changes in fecal water content were assessed, and serum i...

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