期刊论文

中文

数字中医药(英文)

2096-479X

2023

6

02

160-169

10.1016/j.dcmed.2023.07.006

本校为第一机构

目的 研究黄腻苔人群的舌苔和肠道微生物菌群结构和代谢特征,探讨黄腻苔人群舌苔和肠道菌群代表性的代谢标志物和代谢通路.方法 于 2021年 12月 1日至 2022年 10月 30日采集黄腻苔及薄白苔受试者的舌苔及大便样本.16S rRNA及宏基因组测序技术对 2组受试者的舌苔和粪便样本进行菌群鉴定;并对 2组样品进行菌群α-多样性分析、主成分分析(PCA)和Spearman相关性分析;超高效液相色谱联用串联质谱(UPLC-MS/MS)进行代谢组学分析及代谢通路富集分析.结果 本研究共招募 20例黄腻苔受试者和 19 例薄白苔受试者.在菌群属水平,2 组受试者的舌苔菌群及肠道菌群的优势菌种大致相同,但是相对峰度差异明显,黄腻苔...

Objective To study the composition and function of tongue coating(TC)and gastrointestinal tract(GIT)microbiota in participants with yellow-greasy tongue coating(YGTC),and to ex-plore the representative metabolite markers and pathways in this group.Methods Subjects with YGTC or thin-white tongue coating(TWTC)were recruited from December 1,2021 to October 30,2022,and the TC and fecal samples were collected.Samples were subjected to both whole-genome shotgun(WGS),and 16S rRNA gene sequencing.The α-diversity analysis,principal component analysis(P...