期刊论文

Chen, Nai-Hong

英文

亚洲天然物产研究(英文版)

1028-6020

2016

18

8

765-778

10.1080/10286020.2016.1162787

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81274122, 81373997, 81273629, 81473570, 81373510, U1402221]; National High-Tech R&D Programme (863 Program) [2012AA020303]; National Key Sci-Tech Major Special Item [2012ZX09301002-004, 2012ZX09103101-006]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)Program for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1007]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20121106130001]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7131013]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]

本校为通讯机构

Rg1 has shown multiple pharmacological activities and been considered to be evaluated for hepatic protective activity, as Rg1 could modulate different pathways in various diseases. Herein we assessed its effect and potential mechanism in a newly modified ethanol model. C57BL/6 mice were fed with Lieber-DeCarli liquid diet containing ethanol or isocaloric maltose dextrin as control diet with or without Rg1. Meanwhile, bicyclol was treated as positive drug to compare the efficacy of Rg1 against alcoholic hepatotoxicity. According to our data, Rg1 indeed improved the survival rate and lowered the...