期刊论文

Mo, Miao;Liu, ZB

英文

亚洲药物制剂科学

1818-0876

2020

15

4

416-448

10.1016/j.ajps.2019.08.003

supported by the Huxiang Young Talent Program of Hunan Province （2018RS3005）； The Project of Innovation-driven Plan in Central South University （2020CX048）;the Shenghua Yuying Project of Central South University;Postgraduate Independent Exploration and Innovation Project of Central South University （2019zzts1017, 2019zzts750）； Hunan Provincial Natural Science Foundation of China （2019JJ60071,2020JJ4680）； the Hunan Provincial Postgraduate Research and Innovation Project （CX20190242）； the Key Research Fund of Hunan Provincial Education Department （18A211）；

本校为其他机构

Conventional tumor-targeted drug delivery systems (DDSs) face challenges, such as unsatisfied systemic circulation, low targeting efficiency, poor tumoral penetration, and uncontrolled drug release. Recently, tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dilemmas. With the introduction of several additional functionalities, the properties of these smart DDSs including size, surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting, and eventually achieve desired drug release for an optimiz...