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Expressions of genes related to genome stability and DNA repair in nasopharyngeal carcinoma clustering families

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成果类型:
期刊论文
作者:
Xiaojun Zhou*;Daofa Tian(田道法);Shizhen Wang;Yan Ruana;Baoshan Qju;...
通讯作者:
Xiaojun Zhou
作者机构:
[Lu B.; Zhang L.; Zhou X.] E.N.T Department of Zhongshan Hospital Affiliated, Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, China
[Tian D.] Combine Traditional Chinese and Western Medicine Department, Hunan University of Traditional Chinese Medicine, Changsha 410007, China
[Wang S.; Ruan Y.; Qiu B.] E.N.T Department of First Hospital Affiliated, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China
通讯机构:
[Xiaojun Zhou] T
The E.N.T Department of Zhongshan Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, China
语种:
英文
关键词:
Cancer clustering families;Gene chip;Genome stability and DNA repair gene;Nasopharyngeal carcinoma (NPC);Real-time fluorescence quantitative PCR;Ubiquitin
关键词(中文):
DNA修复基因;家庭成员;相关基因;鼻咽癌;稳定性;实时荧光定量PCR;全国人民代表大会;基因芯片技术
期刊:
肿瘤学与转化医学:英文版
ISSN:
2095-9621
年:
2009
卷:
8
期:
12
页码:
713-718
基金类别:
Correspondence to: Xiaojun Zhou. Email: zd1232@126.com * Supported by a grant from the National Natural Science Foundation of China (No. 30672713).
机构署名:
本校为第一机构
摘要:
Objective: The aim of the study was to observe the expressions of genes related to genome stability and DNA repair in the members of nasopharyngeal carcinoma (NPC) clustering families. Methods: In the Zhongshan City where there is highly incidence rate of NPC, we chose the members of the NPC clustering families as objects, and the patients of nasopharyngitis and NPC as the control group. We isolated the RNA from the nasopharyngeal tissue, and synthesized its cRNA, the genome stability and DNA repair genes chip technique, chemiluminescent detect...
摘要(中文):
学习的目的是在聚类家庭的鼻咽的癌(NPC ) 的成员观察与染色体稳定性和 DNA 修理有关的基因的表情的目的。有的中山城市里的方法高度 NPC 的发生率,我们选择了作为鼻咽炎的目标,和病人聚类家庭的 NPC 和 NPC 的成员为控制组。我们从鼻咽的织物孤立 RNA,并且综合它的 cRNA,染色体稳定性和 DNA 修理基因薄片技术, chemiluminescent 察觉和即时荧光量的技术被用来在鼻咽的织物检验染色体稳定性和 DNA 修理基因。结果更多的染色体稳定性和 DNA 修理基因在比 NPC 病人,和范围聚类家庭的 NPC 的成员是起来调整的起来调整高,与过去起来调整的 100 次基因包括 TEP1, MSH4, PMS2L1。更少染色体稳...

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