期刊论文

Extracts from Lindera aggregata(Sims)Kosterm for intervention of alcoholic liver disease in rats

中文

浙江医学

1006-2785

2018

40

6

551-553,572,后插2

10.12056/j.issn.1006-2785.2018.40.6.2017-1052

81503328:国家自然科学基金 2015DTA021:浙江省医药卫生平台项目 2016C33184:浙江省科技厅公益性技术应用研究计划 2014A33339:科技计划

本校为其他机构

目的 观察乌药不同提取物对酒精性肝损伤模型大鼠门静脉内毒素(ET)及小肠组织形态学的影响.方法 选取雄性SD大鼠88只随机分为8组,每组11只,分别为正常对照组、模型对照组、阳性对照组、乌药水提取物组、乌药醇提取物组、乌药醇提取物石油醚萃取物组、乌药醇提取物乙酸乙酯萃取物组、乌药醇提取物正丁醇萃取物组.除正常对照组(以等体积蒸馏水灌胃)外,其余各组大鼠均给予乙醇体积分数50％的白酒以1.2ml/100g连续灌胃33d建立酒精性肝损伤模型,造模同时给予阳性药物及乌药提取物1.0ml/100g连续灌胃,正常对照组及模型对照组给予等量蒸馏水.末次给药后禁食12h取血,测定门静脉ET、TNF-α含量;迅速处死并...

Objective To investigate the efficacy of extracts from Lindera aggregata (Sims) Kosterm in intervention of alcoholic liver disease in rats.Methods Eighty eight male SD rats were divided into 8 groups with 11 in each group:normal control group,model group,positive control group,WYSTW,WYCTW,WYCTC1,WYCTC2 and WYCTC3.The alcoholic liver disease was induced by intragastrical administration of 1.2 mL liquor (50％ v/v)/100 g body weight for 33 days,at the same time the different extracts of Lindera aggregata (Sims) Kosterm were given to rats in variou...