期刊论文

Li, J.-P.

中文

中国中药杂志

1001-5302

2014

39

16

3203-3207

10.4268/cjcmm20141641

国家自然科学基金面上项目

本校为其他机构

该文提出了多维组学新概念,指出多维组学是研究中药复方药效物质基础与机制研究的恰当方法。以壮骨止痛胶囊抗实验性绝经后骨质疏松作用为例,从中药化学组学、基因转录组学、蛋白质组学等三维组学角度,较系统地阐明了壮骨止痛胶囊防治绝经后骨质疏松的药效物质与作用机制,同时,创造性地设计了一个三维表格直观地展现三维组学研究结果。该研究为中药复方药效物质和作用机制研究提供了一种新的思考方式和解决方案。

To propose the new concept of multidimensional omics, and define that the multidimensional omics is a proper method for studying the material base and mechanism of traditional Chinese medicine (TCM) compounds. Zhuanggu Zhitong capsule was taken for example to study its effect against experimental postmenopausal osteoporosis. From the perspective of chemi-omics, genomics and proteomics of TCM, it systematically interpreted the efficacious materials and mechanisms of Zhuanggu Zhitong capsule in preventing and treating experimental postmenopausal osteoporosis, while taking the lead in designing a...