Health Research Project of Hunan Provincial Health Commission [W20243071]; Joint Project of Hunan Provincial Natural Science Foundation [2024JJ9448]; General Guidance Project of Hunan Provincial Administration of Traditional Chinese Medicine [C2023044, B2023077]; Hunan Provincial Natural Science Foundation Project [2022JJ70108]; Key Project of Hunan Provincial Department of Education [22A0279]; Research Fund Project of Hunan University of Traditional Chinese Medicine [2022XYLH027]; Construction Project of National Famous Traditional Chinese Medicine Expert Inheritance Studio in 2022 [75]
机构署名：
本校为第一且通讯机构
院系归属：
第二中医临床医学院
中西医结合学院
摘要：
This study was designed to investigate the role of Ligustrum lucidum Ait and Ecliptae Herba on premature ovarian failure (POF) and the underlying mechanisms. In the POF mouse model constructed using cyclophosphamide (CTX), Ligustrum lucidum Ait and Ecliptae Herba increased ovarian index and estradiol (E2) levels and curtailed motility and follicle-stimulating hormone (FSH). Ligustrum lucidum Ait and Ecliptae Herba alleviated ovarian pathological damage in POF mice and promoted the expression of ovarian CD31 and Vascular Endothelial Growth Factor A (VEGFA). Through high-performance liquid chrom...
