期刊论文

中文

当代医药论丛

2095-7629

2013

11

12

287-289

本校为第一机构

目的:探讨妇科千金胶囊对SD孕鼠分娩及授乳力的影响,对该药的生殖安全性进行研究.方法:采用健康育龄SD雌鼠为模型系统,设妇科千金胶囊不同剂量,并设溶剂对照,进行体内染毒.观察其对健康育龄SD孕鼠分娩及授乳状态等的影响.结果:各剂量染毒组孕鼠哺乳期体重变化及摄食量变化与溶剂对照组比较,未见明显差异(p＞0.05).各实验组母鼠在平均孕程、平均产仔数、仔鼠性别比等方面与溶剂对照组比较,也未见明显差异(p＞0.05).各剂量组仔鼠各时间段死亡率与溶剂对照组比较,也未见明显差异(P＞0.05). 结论:在本研究设定的条件下,妇科千金胶囊在7.68g/kg给药剂量范围内对健康育龄SD孕鼠分娩及授乳无明显毒性.

Objective:By observing the affect of the ability 0f labour and suckle on SD rats for FuKe QianJin Capsules, It is able to open out its reproductive toxicity.Methods:To adopt FuKe QianJin Capsules in differ doses, and by compared with differ groups, we inspect pregnant rats on the ability 0f labour and suckle it is able to open out its reproductive toxicity. Results:the experiment effects indicate that it is' t affected on average incubation time 、litter size、F1 sex ration. it is' t affected on weightness、appetite on pregnant rats too。 it is...