期刊论文

Effct of Yuxianling granule on cognitive dysfunction and ultrastructure of hippocampus CA3 area in PTZ-induced epileptic rats

中文

湖南中医药大学学报

1674-070X

2009

29

3

17-20

10.3969/j.issn.1674-070X.2009.03.006

（基金项目）湖南省自然科学基金资助项目（08JJ5001） 湖南省教育厅重点科研基金资助项目（06A051）.

本校为第一机构

目的 探讨愈痫灵颗粒(YXL)对痫性大鼠海马CA3区超微结构及认知功能障碍的影响.方法 采用腹腔注射戊四氮点燃癫痫大鼠模型,随机分为癫痫模型组、愈痫灵颗粒干预组、丙戊酸钠干预组、拉莫三嗪干预组、正常对照组共5组;跳台实验测试大鼠的学习记忆能力,透射电镜观察海马CA3区超微结构.结果 造模后反应期和学习成绩比较,正常组与其它各组差异有统计学意义(P0.05);抗痫药物干预后各组反应期和潜伏期及学习、记忆成绩比较差异有显著统计学意义(P0.05),愈痫灵组、拉莫三嗪组优于丙戊酸钠组与模型组,差异有统计学意义(P0.05),学习成绩差异有统计学意义(P

Objective To investigate the effect of Yuxianling granules （YXL）on epileptic hippocampus CA3 area ultrastructure and cognitive function. Methods The epilepsy rat models, induced by intraperitoneal injection of pentylenetetrazol, were randomly divided into model （model）, Yuxianling granules intervention, valproate intervention, lamotrigine intervention, and control groups; the learning and memory ability of rats were tested with experimental platform, and the ultrastructure of hippocampal CA3 area with transmission eleetron microscopy observ...