[Liu, Xing; Wen, Jia; Li, Ying; Xing, Xiao-Wei; Yuan, Hong; Lu, Yao; Huang, Li-Hua; Xing, XW; Huang, Yun; Miao, Ru-Jia] Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, 138 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

[Huang, Yun] Lihuili Hosp, Dept Pharm, Ningbo Med Ctr, Ningbo 315000, Zhejiang, Peoples R China.

[Liu, Xiao-Li] Hunan Univ Tradit Chinese Med, Dept Pharm, Affiliated Hosp 2, Changsha 410013, Hunan, Peoples R China.

[Xing, XW; Yuan, H ] C

Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, 138 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

adenovirus vector;beta 1 adrenergic receptor;metoprolol;short hairpin RNA;antihypertensive agent;beta 1 adrenergic receptor;metoprolol;small interfering RNA;Adeno associated virus 9;animal experiment;animal model;animal tissue;antihypertensive activity;Article;blood pressure regulation;cardiac muscle;controlled study;drug sensitivity;essential hypertension;gene expression;heart rate;in vivo study;male;nonhuman;protein synthesis inhibition;rat;receptor down regulation;spontaneously hypertensive rat;systolic blood pressure;animal;blood pressure;cardiac muscle;cell line;chemistry;Dependoparvovirus;down regulation;drug effects;gene vector;genetics;HEK293 cell line;human;hypertension;metabolism;pathology;RNA interference;Animals;Antihypertensive Agents;Blood Pressure;Cell Line;Dependovirus;Down-Regulation;Genetic Vectors;Heart Rate;HEK293 Cells;Humans;Hypertension;Male;Metoprolol;Myocardium;Rats;Rats, Inbred SHR;Receptors, Adrenergic, beta-1;RNA Interference;RNA, Small Interfering

第二中医临床医学院

药学院