Downregulation of the beta 1 adrenergic receptor in the myocardium results in insensitivity to metoprolol and reduces blood pressure in spontaneously hypertensive rats

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成果类型：

期刊论文

作者：

Huang, Yun;Liu, Xiao-Li;Wen, Jia;Huang, Li-Hua;Lu, Yao;...

通讯作者：

Xing, Xiao-Wei;Yuan, Hong

作者机构：

[Liu, Xing; Wen, Jia; Li, Ying; Xing, Xiao-Wei; Yuan, Hong; Lu, Yao; Huang, Li-Hua; Xing, XW; Huang, Yun; Miao, Ru-Jia] Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, 138 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

[Huang, Yun] Lihuili Hosp, Dept Pharm, Ningbo Med Ctr, Ningbo 315000, Zhejiang, Peoples R China.

[Liu, Xiao-Li] Hunan Univ Tradit Chinese Med, Dept Pharm, Affiliated Hosp 2, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Xing, XW; Yuan, H] C

Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, 138 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

beta 1 adrenergic receptor;myocardium;metoprolol;recombinant adeno-associated virus type 9 vector;blood pressure;spontaneously hypertensive rats

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2017

卷：

期：

页码：

703-711

DOI：

10.3892/mmr.2016.6038

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470535]; National Science and Technology Major Projects for 'Major New Drugs Innovation and Development' [2012ZX09303014001]; National Key Technology Research and Development ProgramNational Key Technology R&D Program [2012BAI137B05]

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

药学院

摘要：

The beta 1-adrenergic receptor (AR) is the primary beta-AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension. Previous studies have revealed a positive correlation between the methylation levels of the adrenoreceptor beta 1 gene (Adrb1) promoter in the myocardium with the antihypertensive activity of Met in spontaneously hypertensive rats (SHR), which affects beta 1-AR expression in H9C2 cells. The aim of the present study was to investigate the effects of myocardial beta 1-AR downregulation using short-hairpin RNA (shRNA) again...

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Downregulation of the beta 1 adrenergic receptor in the myocardium results in insensitivity to metoprolol and reduces blood pressure in spontaneously hypertensive rats

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