Possible target-related proteins of stress-resistant rats suggested by label-free proteomic analysis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Jiao;Wang, Zhenzhen;Zhang, Shuai;Ai, Qidi;Chu, Shifeng;...

通讯作者：

Chen, Nai-hong

作者机构：

[Chen, Nai-hong; Wang, Zhenzhen; Zhang, Shuai; Chen, Jiao; Chu, Shifeng] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.

[Chen, Nai-hong; Wang, Zhenzhen; Zhang, Shuai; Chen, Jiao; Chu, Shifeng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Chen, Nai-hong; Wang, Zhenzhen; Zhang, Shuai; Chen, Jiao; Chu, Shifeng] Peking Union Med Coll, Beijing 100050, Peoples R China.

[Ai, Qidi; Chen, Nai-hong] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Chen, Nai-hong] Guangzhou Univ Chinese Med, Guangzhou 510000, Guangdong, Peoples R China.

通讯机构：

[Chen, Nai-hong] C

[Chen, Nai-hong] P

[Chen, Nai-hong] H

[Chen, Nai-hong] G

Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2017

卷：

期：

页码：

40957-40964

DOI：

10.1039/c7ra04212d

基金类别：

National Natural Science Foundation of China [81274122, 81202507, U1402221, 81573636]; National Mega-project for Innovative Drugs [2012ZX09301002-004, 2012ZX09301002-001]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [IRT1007]; Specialized Research Fund for the Doctoral Program of Higher Education of China [20121106130001]; Beijing Natural Science Foundation [7131013, 7142115]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]; State Key Laboratory Fund Open Project [GTZK201610]; China Postdoctoral Science Foundation [2013M540066]

机构署名：

本校为通讯机构

摘要：

Stress plays a crucial role in the development of major depressive disorder, but the molecular mechanism underlying the susceptibility vs. resilience to stress remains unclear. To better understand these mechanisms, we used chronic unpredictable mild stress to develop a depressive rat model. We categorized them into stress resistant rats and stress sensitive rats by their performance in behavioral tests, including forced swim test and sucrose preference test. Brain regions were dissected, and prefrontal cortex (PFC) proteins extracted from stress resistant and stress sensitive rats were analyz...

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Possible target-related proteins of stress-resistant rats suggested by label-free proteomic analysis

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